Mini-Mu insertions in the tetracycline resistance determinant from Proteus mirabilis
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Mini-Mu insertions in the tetracycline resistance determinant from Proteus mirabilis.
The inducible tetracycline resistance determinant isolated from Proteus mirabilis cloned into the plasmid pACYC177 was mutagenized by insertion of a mini-Mu-lac phage in order to define the regions in the cloned sequences encoding the structural and regulatory proteins. Three different types of mutants were obtained: one lost the resistance phenotype and became Lac+; another expressed the resis...
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ژورنال
عنوان ژورنال: Brazilian Journal of Medical and Biological Research
سال: 1997
ISSN: 0100-879X
DOI: 10.1590/s0100-879x1997000300009